Brexanolone (Zulresso).
A prescription medication used to treat postpartum depression (PPD), a condition that affects women after giving birth.
- Common Brand Name(s): Brexanolone
- Common Generic Name(s): Zulresso
- Pronunciation:(brex ANN oh lone)
Whats is Brexanolone?
A treatment for moderate-to-severe postpartum depression (PPD) that is administered through intravenous injection (IV). It helps by balancing substances in your brain to help regulate emotions.
Zulresso for intravenous use – 100 mg/20 mL
Zulresso (brexanolone) is a gamma-aminobutyric acid A (GABAA) receptor positive allosteric modulator indicated for the treatment of postpartum depression (PPD).
Conditions Treated with Brexanolone (Zulresso)
Postpartum Depression
Side Effects
Buprenorphine can cause a range of side effects, some common and others more serious. It’s important to be aware of these potential effects and to discuss any concerns with your doctor.
Common Side Effects:
- dizziness or lightheadedness
- drowsiness
- fainting
- feeling of constant movement of self or surroundings
- relaxed and calm feeling
- sensation of spinning
- sleepiness or unusual drowsiness
Less Common Side Effects:
- fast, pounding, or irregular heartbeat or pulse
- loss of consciousness
- acid or sour stomach
- belching
- diarrhea
- feeling of warmth
- heartburn
- indigestion
- mouth or throat pain
- redness of the face, neck, arms, and occasionally, upper chest
- stomach discomfort, upset, or pain
Serious Side Effects:
Get emergency help immediately if any of the following symptoms of overdose occur while taking brexanolone:
Symptom of overdose
- prolonged drowsiness
Sources
- https://www.drugs.com/sfx/zulresso-side-effects.html
- https://my.clevelandclinic.org/health/drugs/21373-brexanolone-injection
- https://www.federalregister.gov/documents/2025/03/14/2025-04101/sage-therapeutics-inc-withdrawal-of-approval-of-a-new-drug-application-for-zulresso-brexanolone#:~:text=Sage%20has%20informed%20FDA%20that,its%20opportunity%20for%20a%20hearing.
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